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Mouse Anti-PGRMC2 Recombinant Antibody (2A3) (CBMAB-A6610-LY)

The product is antibody recognizes PGRMC2. The antibody 2A3 immunoassay techniques such as: WB, ELISA.
See all PGRMC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2A3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PGRMC2 (NP_006311, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Progesterone Receptor Membrane Component 2
Entrez Gene ID
Human10424
Mouse70804
Rat361940
UniProt ID
HumanO15173
MouseQ80UU9
RatQ5XIU9
Alternative Names
DG6; PMBP
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
Biological Process
Adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Nucleus envelope
Endoplasmic reticulum
Topology
Helical: 42-66
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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