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PGRMC2

PGRMC2 has ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.

Full Name

Progesterone Receptor Membrane Component 2

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).

Biological Process

Adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane
Nucleus envelope
Endoplasmic reticulum

Topology

Helical: 42-66

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Anti-PGRMC2 antibodies

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Mouse Anti-PGRMC2 Recombinant Antibody (CF337) (CBMAB-FT162LY)

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Target: PGRMC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CF337

Application*: ELISA, WB

Mouse Anti-PGRMC2 Recombinant Antibody (2A3) (CBMAB-A6610-LY)

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Target: PGRMC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 2A3

Application*: WB, E

Mouse Anti-PGRMC2 Recombinant Antibody (CBYC-P339) (CBMAB-P1633-YC)

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Target: PGRMC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P339

Application*: WB, P, F

Mouse Anti-PGRMC2 Recombinant Antibody (CBYC-P338) (CBMAB-P1632-YC)

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Target: PGRMC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYC-P338

Application*: E, P, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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