PGRMC2
PGRMC2 has ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.
Full Name
Progesterone Receptor Membrane Component 2
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
Biological Process
Adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Nucleus envelope
Endoplasmic reticulum
Nucleus envelope
Endoplasmic reticulum
Topology
Helical: 42-66
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Anti-PGRMC2 antibodies
+ Filters
Target: PGRMC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF337
Application*: ELISA, WB
Target: PGRMC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 2A3
Application*: WB, E
Target: PGRMC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P339
Application*: WB, P, F
Target: PGRMC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-P338
Application*: E, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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