PGRMC2

PGRMC2 has ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.

Progesterone Receptor Membrane Component 2

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).

Adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB

Membrane
Nucleus envelope
Endoplasmic reticulum

Helical: 42-66