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Mouse Anti-PGRMC2 Recombinant Antibody (CBYC-P339) (CBMAB-P1633-YC)

Provided herein is a Mouse monoclonal antibody against Human Progesterone Receptor Membrane Component 2. The antibody can be used for immunoassay techniques, such as WB, IHC-P, FC.
See all PGRMC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P339
Antibody Isotype
IgG1
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Progesterone Receptor Membrane Component 2
Introduction
PGRMC2 has ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.
Entrez Gene ID
10424
UniProt ID
O15173
Alternative Names
Progesterone Receptor Membrane Component 2; Steroid Receptor Protein DG6; PMBP; DG6; Membrane-Associated Progesterone Receptor Component 2; Progesterone Membrane Binding Protein; Progesterone Membrane-Binding Protein;
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).
Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).
In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
Biological Process
Adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Nucleus envelope
Endoplasmic reticulum
Topology
Helical: 42-66
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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