Mouse Anti-PHIP Recombinant Antibody (CBYC-P349) (CBMAB-P1680-YC)

Name: Mouse Anti-PHIP Recombinant Antibody (CBYC-P349)
SKU: CBMAB-P1680-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYC-P349

Application

WB, FC

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

pleckstrin homology domain interacting protein

Introduction

PHIP is a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients.

Entrez Gene ID

55023

UniProt ID

Q8WWQ0

Alternative Names

Pleckstrin Homology Domain Interacting Protein; DDB1 And CUL4 Associated Factor 14; IRS-1 PH Domain-Binding Protein; WD Repeat-Containing Protein 11; WDR11; PH-Interacting Protein; DCAF14; BRWD2; Ndrp;

Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Insulin receptor signaling pathway1 PublicationNAS:UniProtKB
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Positive regulation of cell population proliferationISS:UniProtKB
Positive regulation of insulin-like growth factor receptor signaling pathwayISS:UniProtKB
Positive regulation of mitotic nuclear divisionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein phosphorylationISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Chung-Jansen syndrome (CHUJANS):
An autosomal dominant disorder characterized by developmental delay, intellectual disability, autistic features, anxiety, hypotonia, obesity, and dysmorphic features.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PHIP Recombinant Antibody (4D7) (CAT#: CBMAB-P1678-YC)

Mouse Anti-PHIP Recombinant Antibody (B-1) (CAT#: CBMAB-P1679-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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