PHIP

PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM

pleckstrin homology domain interacting protein

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Insulin receptor signaling pathway1 PublicationNAS:UniProtKB
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Positive regulation of cell population proliferationISS:UniProtKB
Positive regulation of insulin-like growth factor receptor signaling pathwayISS:UniProtKB
Positive regulation of mitotic nuclear divisionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein phosphorylationISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Nucleus

Chung-Jansen syndrome (CHUJANS):
An autosomal dominant disorder characterized by developmental delay, intellectual disability, autistic features, anxiety, hypotonia, obesity, and dysmorphic features.