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Mouse Anti-PIGR Recombinant Antibody (CBXS-0054) (CBMAB-S3055-CQ)

This product is a mouse antibody that recognizes PIGR. The antibody CBXS-0054 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all PIGR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0054
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Polymeric Immunoglobulin Receptor
Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
polymeric immunoglobulin receptor
Introduction
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
Entrez Gene ID
5284
UniProt ID
P01833
Alternative Names
Polymeric Immunoglobulin Receptor; Hepatocellular Carcinoma-Associated Protein TB6; Poly-Ig Receptor; PIgR;
Function
Polymeric immunoglobulin receptor
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Secretory component
Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896).
On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
Biological Process
Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Fc receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorManual Assertion Based On ExperimentIDA:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIDA:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Polymeric immunoglobulin receptor
Cell membrane
Secretory component
Secreted
Topology
Extracellular: 19-638
Helical: 639-661
Cytoplasmic: 662-764
PTM
N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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