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PIGR

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene

Full Name

polymeric immunoglobulin receptor

Function

Polymeric immunoglobulin receptor
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Secretory component
Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896).
On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).

Biological Process

Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Fc receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorManual Assertion Based On ExperimentIDA:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIDA:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Polymeric immunoglobulin receptor
Cell membrane
Secretory component
Secreted

Topology

Extracellular: 19-638
Helical: 639-661
Cytoplasmic: 662-764

PTM

N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.

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Anti-PIGR antibodies

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Rat Anti-PIGR Recombinant Antibody (7C1) (CBMAB-P1765-YC)

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Target: PIGR

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 7C1

Application*: IH, WB

Rabbit PIGR ELISA Kit (V2LY-0626-LY318)

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Target: PIGR

Sensitivity: 9.55 ng/mL

Detection Range: 20-4500 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rabbit

Assay Type: Sandwich

Reactivity: Rabbit

Mouse Pigr ELISA Kit (V2LY-0626-LY1530)

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Target: Pigr

Sensitivity: 0.0093 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Mouse Recombinant PIGR protein, His Tag (V2LY-0526-LY8778)

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Target: PIGR

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-645

Tag: His Tag

Human Recombinant PIGR (365 Ser/Gly) protein, His Tag (V2LY-0526-LY6170)

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Target: PIGR

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-638, 365/

Tag: His Tag

Mouse Anti-PIGR Recombinant Antibody (CBT3806) (V2LY-0625-LY1060)

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Target: PIGR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3806

Application*: IH

Mouse Anti-PIGR Recombinant Antibody (CBT3003) (V2LY-0625-LY1059)

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Target: PIGR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3003

Application*: IH

Mouse Anti-pIgR Recombinant Antibody (CBYC-P374) (CBMAB-P1767-YC)

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Target: PIGR

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBYC-P374

Application*: WB

Mouse Anti-pIgR Recombinant Antibody (CBYC-P373) (CBMAB-P1766-YC)

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Target: PIGR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P373

Application*: B

Mouse Anti-PIGR Recombinant Antibody (2G5) (CBMAB-P1764-YC)

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Target: PIGR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G5

Application*: E, WB

Mouse Anti-PIGR Recombinant Antibody (CBXS-0054) (CBMAB-S3055-CQ)

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Target: PIGR

Host: Mouse

Specificity: Human

Clone: CBXS-0054

Application*: WB, IC, P, C, E

Rabbit Anti-PIGR (AA 1-645) Recombinant Antibody (CBFYM-3056) (CBMAB-M3252-FY)

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Target: PIGR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYM-3056

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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