Sign in or Register

PIGR

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene
Full Name
polymeric immunoglobulin receptor
Function
Polymeric immunoglobulin receptor
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Secretory component
Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896).
On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
Biological Process
Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Fc receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorManual Assertion Based On ExperimentIDA:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIDA:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Polymeric immunoglobulin receptor
Cell membrane
Secretory component
Secreted
Topology
Extracellular: 19-638
Helical: 639-661
Cytoplasmic: 662-764
PTM
N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
View more

Anti-PIGR antibodies

+ Filters
Loading...

Rat Anti-PIGR Recombinant Antibody (7C1) (CBMAB-P1765-YC)

Go to compareCompare
Target: PIGR
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7C1
Application*: IH, WB
Datasheet SDS

Mouse Anti-PIGR Recombinant Antibody (CBT3806) (V2LY-0625-LY1060)

Go to compareCompare
Target: PIGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3806
Application*: IH
Datasheet SDS

Mouse Anti-PIGR Recombinant Antibody (CBT3003) (V2LY-0625-LY1059)

Go to compareCompare
Target: PIGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3003
Application*: IH
Datasheet SDS

Mouse Anti-pIgR Recombinant Antibody (CBYC-P374) (CBMAB-P1767-YC)

Go to compareCompare
Target: PIGR
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYC-P374
Application*: WB
Datasheet SDS

Mouse Anti-pIgR Recombinant Antibody (CBYC-P373) (CBMAB-P1766-YC)

Go to compareCompare
Target: PIGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P373
Application*: B
Datasheet SDS

Mouse Anti-PIGR Recombinant Antibody (2G5) (CBMAB-P1764-YC)

Go to compareCompare
Target: PIGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G5
Application*: E, WB
Datasheet SDS

Mouse Anti-PIGR Recombinant Antibody (CBXS-0054) (CBMAB-S3055-CQ)

Go to compareCompare
Target: PIGR
Host: Mouse
Specificity: Human
Clone: CBXS-0054
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-PIGR (AA 1-645) Recombinant Antibody (CBFYM-3056) (CBMAB-M3252-FY)

Go to compareCompare
Target: PIGR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-3056
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry