Mouse Anti-PIGR Recombinant Antibody (2G5) (CBMAB-P1764-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Secretory component
Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896).
On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Fc receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorManual Assertion Based On ExperimentIDA:UniProtKB
Receptor clusteringManual Assertion Based On ExperimentIDA:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cell membrane
Secretory component
Secreted
Helical: 639-661
Cytoplasmic: 662-764
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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