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Mouse Anti-PI4KB Recombinant Antibody (3B1) (CBMAB-A6692-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B1
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
PIK4CB (NP_002642.1, 731 a.a. ~ 828 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphatidylinositol 4-Kinase Beta
Entrez Gene ID
5298
UniProt ID
Q9UBF8
Alternative Names
PI4K-BETA; PI4KIIIbeta; PI4Kbeta; PIK4CB; pi4K92
Function
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260).
Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Biological Process
Lysosome organizationManual Assertion Based On ExperimentIDA:MGI
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endomembrane system
Mitochondrion outer membrane
Rough endoplasmic reticulum membrane
Golgi apparatus
Golgi apparatus membrane
Cytoplasm, perinuclear region
Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207).
GGA2 is also involved in the recruitment (PubMed:28289207).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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