PI4KB

PI4KB has ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.6) and 25 other tissues.

Full Name

Phosphatidylinositol 4-Kinase Beta

Function

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260).
Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.

Biological Process

Lysosome organizationManual Assertion Based On ExperimentIDA:MGI
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endomembrane system
Mitochondrion outer membrane
Rough endoplasmic reticulum membrane
Golgi apparatus
Golgi apparatus membrane
Cytoplasm, perinuclear region
Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207).
GGA2 is also involved in the recruitment (PubMed:28289207).