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Mouse Anti-PIP4K2C Recombinant Antibody (3A4) (CBMAB-P1875-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PIP4K2C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A4
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
PIP4K2C (NP_079055.2, 310-381 aa) partial recombinant protein with GST tag. Immunogen sequence: DGDCSLTGPP ALVGSYGTSP EGIGGYIHSH RPLGPGEFES FIDVYAIRSA EGAPQKEVYF MGLIDILTQY DA
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 310-381

Target

Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Introduction
PIP4K2C has ubiquitous expression in testis (RPKM 18.0), kidney (RPKM 16.8) and 25 other tissues.
Entrez Gene ID
79837
UniProt ID
Q8TBX8
Alternative Names
Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma; Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Gamma; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma; PI(5)P 4-Kinase Type II Gamma; PIP4KII-Gamma; EC 2.7.1.149;
Function
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Biological Process
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Endoplasmic reticulum
Cytoplasm
PTM
Phosphorylated, phosphorylation is induced by EGF.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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