Mouse Anti-PIP4K2C Recombinant Antibody (3A4) (CBMAB-P1875-YC)

Name: Mouse Anti-PIP4K2C Recombinant Antibody (3A4)
SKU: CBMAB-P1875-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

3A4

Application

ELISA, WB

Immunogen

PIP4K2C (NP_079055.2, 310-381 aa) partial recombinant protein with GST tag. Immunogen sequence: DGDCSLTGPP ALVGSYGTSP EGIGGYIHSH RPLGPGEFES FIDVYAIRSA EGAPQKEVYF MGLIDILTQY DA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 310-381

More Infomation

Target

Full Name

phosphatidylinositol-5-phosphate 4-kinase, type II, gamma

Introduction

PIP4K2C has ubiquitous expression in testis (RPKM 18.0), kidney (RPKM 16.8) and 25 other tissues.

Entrez Gene ID

79837

UniProt ID

Q8TBX8

Alternative Names

Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma; Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Gamma; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma; PI(5)P 4-Kinase Type II Gamma; PIP4KII-Gamma; EC 2.7.1.149;

Function

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).

Biological Process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum
Cytoplasm

PTM

Phosphorylated, phosphorylation is induced by EGF.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PIP4K2C Recombinant Antibody (3E10) (CAT#: CBMAB-A6715-LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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