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Mouse Anti-PIP4K2C Recombinant Antibody (3E10) (CBMAB-A6715-LY)

The product is antibody recognizes PIP4K2C. The antibody 3E10 immunoassay techniques such as: sELISA, ELISA.
See all PIP4K2C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E10
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
PIP4K2C (NP_079055.2, 310 a.a. ~ 381 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Entrez Gene ID
UniProt ID
Alternative Names
FLJ22055; PIP5K2C
Function
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Biological Process
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Endoplasmic reticulum
Cytoplasm
PTM
Phosphorylated, phosphorylation is induced by EGF.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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