PIP4K2C

PIP4K2C has ubiquitous expression in testis (RPKM 18.0), kidney (RPKM 16.8) and 25 other tissues.

Full Name

phosphatidylinositol-5-phosphate 4-kinase, type II, gamma

Function

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).

Biological Process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum
Cytoplasm

PTM

Phosphorylated, phosphorylation is induced by EGF.