Mouse Anti-PIR Recombinant Antibody (2740C2) (CBMAB-P1883-YC)

Name: Mouse Anti-PIR Recombinant Antibody (2740C2)
SKU: CBMAB-P1883-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

2740C2

Application

Dot, FC, IP, WB

Immunogen

Recombinant human Pirin (Iron-Binding Nuclear Protein) (Pir)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pirin

Introduction

PIR is a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.

Entrez Gene ID

8544

UniProt ID

O00625

Alternative Names

Pirin; Probable Quercetin 2,3-Dioxygenase PIR; Pirin (Iron-Binding Nuclear Protein); Probable Quercetinase; EC 1.13.11.24;

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

Biological Process

DigestionTAS:Reactome
Monocyte differentiationManual Assertion Based On ExperimentIMP:MGI
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

PIR Matched Antibody Pair (880) (CAT#: APMAB-880LY)

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PIR Matched Antibody Pair (880) (CAT#: APMAB-880LY)

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Rat Anti-PIR Recombinant Antibody (7H52) (CAT#: CBMAB-P1885-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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