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PIR

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Full Name

Pirin

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

Biological Process

DigestionTAS:Reactome
Monocyte differentiationManual Assertion Based On ExperimentIMP:MGI
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

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Anti-PIR antibodies

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PIR Matched Antibody Pair (880) (APMAB-880LY)

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Target: PIR

Specificity: Human

Rat Anti-PIR Recombinant Antibody (7H52) (CBMAB-P1885-YC)

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Target: PIR

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Human, Cattle, Hamster, Monkey, Mouse, Rat

Clone: 7H52

Application*: E, F, IP, WB

Mouse Anti-PIR Recombinant Antibody (4D1) (CBMAB-P1884-YC)

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Target: PIR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4D1

Application*: WB

Mouse Anti-PIR Recombinant Antibody (2740C2) (CBMAB-P1883-YC)

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Target: PIR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2740C2

Application*: DB, F, IP, WB

Rat Anti-PIR Recombinant Antibody (1E8) (CBMAB-P1882-YC)

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Target: PIR

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Hamster, Monkey, Cattle

Clone: 1E8

Application*: WB, IPF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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