PIR

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Full Name
Pirin
Function
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Biological Process
DigestionTAS:Reactome
Monocyte differentiationManual Assertion Based On ExperimentIMP:MGI
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
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Anti-PIR antibodies

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PIR Matched Antibody Pair (880) (APMAB-880LY)

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Target: PIR
Specificity: Human
Datasheet SDS

Rat Anti-PIR Recombinant Antibody (7H52) (CBMAB-P1885-YC)

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Target: PIR
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Cattle, Hamster, Monkey, Mouse, Rat
Clone: 7H52
Application*: E, F, IP, WB
Datasheet SDS

Mouse Anti-PIR Recombinant Antibody (4D1) (CBMAB-P1884-YC)

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Target: PIR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D1
Application*: WB
Datasheet SDS

Mouse Anti-PIR Recombinant Antibody (2740C2) (CBMAB-P1883-YC)

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Target: PIR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2740C2
Application*: DB, F, IP, WB
Datasheet SDS

Rat Anti-PIR Recombinant Antibody (1E8) (CBMAB-P1882-YC)

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Target: PIR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Hamster, Monkey, Cattle
Clone: 1E8
Application*: WB, IPF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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