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Rat Anti-PIR Recombinant Antibody (7H52) (CBMAB-P1885-YC)

Provided herein is a Rat monoclonal antibody against Human Pirin. The antibody can be used for immunoassay techniques, such as ELISA, FC, IP, WB.
See all PIR antibodies

Summary

Host Animal
Rat
Specificity
Human, Cattle, Hamster, Monkey, Mouse, Rat
Clone
7H52
Antibody Isotype
IgG2a, κ
Application
ELISA, FC, IP, WB

Basic Information

Specificity
Human, Cattle, Hamster, Monkey, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in 10 mM HEPES, pH 7.5, 150 mM sodium chloride, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pirin
Introduction
PIR is a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human8544
Mouse69656
Rat363465
Cattle790878
Monkey720959
Hamster101823289
UniProt ID
HumanO00625
MouseQ9D711
RatQ5M827
CattleA6QQH1
MonkeyF6S6S2
HamsterA0A061HUL9
Alternative Names
Pirin; Probable Quercetin 2,3-Dioxygenase PIR; Pirin (Iron-Binding Nuclear Protein); Probable Quercetinase; EC 1.13.11.24;
Function
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Biological Process
DigestionTAS:Reactome
Monocyte differentiationManual Assertion Based On ExperimentIMP:MGI
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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