Rat Anti-PIR Recombinant Antibody (7H52) (CBMAB-P1885-YC)

Name: Rat Anti-PIR Recombinant Antibody (7H52)
SKU: CBMAB-P1885-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

7H52

Application

ELISA, FC, IP, WB

Specificity

Human, Cattle, Hamster, Monkey, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in 10 mM HEPES, pH 7.5, 150 mM sodium chloride, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pirin

Introduction

PIR is a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.

Entrez Gene ID

Human	8544
Mouse	69656
Rat	363465
Cattle	790878
Monkey	720959
Hamster	101823289

UniProt ID

Human	O00625
Mouse	Q9D711
Rat	Q5M827
Cattle	A6QQH1
Monkey	F6S6S2
Hamster	A0A061HUL9

Alternative Names

Pirin; Probable Quercetin 2,3-Dioxygenase PIR; Pirin (Iron-Binding Nuclear Protein); Probable Quercetinase; EC 1.13.11.24;

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

Biological Process

DigestionTAS:Reactome
Monocyte differentiationManual Assertion Based On ExperimentIMP:MGI
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

PIR Matched Antibody Pair (880) (CAT#: APMAB-880LY)

Related Products

Rat Anti-PIR Recombinant Antibody (1E8) (CAT#: CBMAB-P1882-YC)

Mouse Anti-PIR Recombinant Antibody (2740C2) (CAT#: CBMAB-P1883-YC)

Mouse Anti-PIR Recombinant Antibody (4D1) (CAT#: CBMAB-P1884-YC)

PIR Matched Antibody Pair (880) (CAT#: APMAB-880LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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