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Mouse Anti-PKP2 Recombinant Antibody (8H6) (CBMAB-1668-CN)

This product is a mouse antibody that recognizes PKP2 of human. The antibody 8H6 can be used for immunoassay techniques such as: FC, IHC-P, IP, WB.
See all PKP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
8H6
Antibody Isotype
IgG1
Application
FC, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant fragment, corresponding to aa. 1-350 of Human Plakophilin 2 fused to maltose binding protein.
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
99% PBS
Preservative
0.1% Sodium Azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
plakophilin 2
Introduction
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. The protein may play a role in junctional plaques.
Entrez Gene ID
Human5318
Mouse67451
UniProt ID
HumanQ99959
MouseQ9CQ73
Alternative Names
ARVD9
Function
May play a role in junctional plaques.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationManual Assertion Based On ExperimentIMP:BHF-UCL
Cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Cell communication by electrical coupling involved in cardiac conductionISS:BHF-UCL
Cell-cell adhesionISS:BHF-UCL
Cell-cell junction assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signaling involved in cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentISS:BHF-UCL
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Maintenance of animal organ identityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sodium ion transportISS:BHF-UCL
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Nucleus
Cell junction, desmosome
Nuclear and associated with desmosomes.
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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