PKP2

PKP2 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskelet

Full Name

plakophilin 2

Function

May play a role in junctional plaques.

Biological Process

Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationManual Assertion Based On ExperimentIMP:BHF-UCL
Cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Cell communication by electrical coupling involved in cardiac conductionISS:BHF-UCL
Cell-cell adhesionISS:BHF-UCL
Cell-cell junction assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signaling involved in cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentISS:BHF-UCL
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Maintenance of animal organ identityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sodium ion transportISS:BHF-UCL
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Nucleus
Cell junction, desmosome
Nuclear and associated with desmosomes.

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.