PKP2

PKP2 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskelet

plakophilin 2

May play a role in junctional plaques.

Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationManual Assertion Based On ExperimentIMP:BHF-UCL
Cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Cell communication by electrical coupling involved in cardiac conductionISS:BHF-UCL
Cell-cell adhesionISS:BHF-UCL
Cell-cell junction assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signaling involved in cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Desmosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentISS:BHF-UCL
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Maintenance of animal organ identityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sodium ion transportISS:BHF-UCL
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL

Nucleus
Cell junction, desmosome
Nuclear and associated with desmosomes.

Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.