Mouse Anti-PLB1 Recombinant Antibody (1B3) (CBMAB-P2041-YC)

Name: Mouse Anti-PLB1 Recombinant Antibody (1B3)
SKU: CBMAB-P2041-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1B3

Application

Immunogen

Full length human recombinant protein of human PLB1(NP_694566) produced in HEK293T cell.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phospholipase B1

Introduction

PLB1 is a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail.

Entrez Gene ID

151056

UniProt ID

Q6P1J6

Alternative Names

hPLB; PLB; PLB/LIP

Function

Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity).
Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity).
Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity).
May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity).
May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity).

Biological Process

Diacylglycerol catabolic processIEA:Ensembl
Phosphatidylcholine acyl-chain remodelingTAS:Reactome
Phosphatidylcholine catabolic processIEA:Ensembl
Phosphatidylethanolamine catabolic processIEA:Ensembl
Phosphatidylglycerol catabolic processIEA:Ensembl
Phospholipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of acrosome reactionIEA:Ensembl
Retinoid metabolic processTAS:Reactome
Triglyceride catabolic processIEA:Ensembl

Cellular Location

Apical cell membrane
Present in the intestinal brush border membranes.

Topology

Extracellular: 22-1417
Helical: 1418-1438
Cytoplasmic: 1439-1458

PTM

Undergoes proteolytic cleavage in the ileum.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PLB1 Recombinant Antibody (CBYC-P424) (CAT#: CBMAB-P2043-YC)

Mouse Anti-PLB1 Recombinant Antibody (1D3) (CAT#: CBMAB-P2042-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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