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Mouse Anti-PLB1 Recombinant Antibody (1D3) (CBMAB-P2042-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipase B1. The antibody can be used for immunoassay techniques, such as WB.
See all PLB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D3
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipase B1
Introduction
PLB1 is a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail.
Entrez Gene ID
151056
UniProt ID
Q6P1J6
Alternative Names
hPLB; PLB; PLB/LIP
Function
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity).
Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity).
Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity).
May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity).
May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity).
Biological Process
Diacylglycerol catabolic processIEA:Ensembl
Phosphatidylcholine acyl-chain remodelingTAS:Reactome
Phosphatidylcholine catabolic processIEA:Ensembl
Phosphatidylethanolamine catabolic processIEA:Ensembl
Phosphatidylglycerol catabolic processIEA:Ensembl
Phospholipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of acrosome reactionIEA:Ensembl
Retinoid metabolic processTAS:Reactome
Triglyceride catabolic processIEA:Ensembl
Cellular Location
Apical cell membrane
Present in the intestinal brush border membranes.
Topology
Extracellular: 22-1417
Helical: 1418-1438
Cytoplasmic: 1439-1458
PTM
Undergoes proteolytic cleavage in the ileum.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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