Rabbit Anti-PLCB2 Recombinant Antibody (N11-S) (CBMAB-P2048-YC)

Name: Rabbit Anti-PLCB2 Recombinant Antibody (N11-S)
SKU: CBMAB-P2048-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

N11-S

Application

WB, ELISA, IP

Immunogen

Peptide derived from the human PKC-betall sequence

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phospholipase C, beta 2

Introduction

PLCB2 is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses.

Entrez Gene ID

Human	5330
Mouse	18796
Rat	85240

UniProt ID

Human	Q00722
Mouse	A3KGF7
Rat	O89040

Alternative Names

PLC-beta-2

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Biological Process

Activation of phospholipase C activityManual Assertion Based On ExperimentTAS:ProtInc
Detection of chemical stimulus involved in sensory perception of bitter tasteIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Phospholipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytosol
G-protein beta/gamma-subunit complex
Golgi apparatus
plasma membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PLCB2 Recombinant Antibody (1B3) (CAT#: CBMAB-P2047-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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