PLCB2

PLCB2 is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses.

Full Name

phospholipase C, beta 2

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Biological Process

Activation of phospholipase C activityManual Assertion Based On ExperimentTAS:ProtInc
Detection of chemical stimulus involved in sensory perception of bitter tasteIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Phospholipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytosol
G-protein beta/gamma-subunit complex
Golgi apparatus
plasma membrane