Mouse Anti-PLCD4 Recombinant Antibody (4D4) (CBMAB-P2053-YC)

Name: Mouse Anti-PLCD4 Recombinant Antibody (4D4)
SKU: CBMAB-P2053-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4D4

Application

ELISA, WB

Immunogen

PLCD4 (AAH06355, 18-128 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PLCD4

Introduction

PLCD4 is a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol.

Entrez Gene ID

84812

UniProt ID

Q9BRC7

Alternative Names

PLC-Delta-4

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Isoform 2
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.

Biological Process

Acrosome reactionIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol metabolic processIEA:InterPro
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionIDA:UniProtKB

Cellular Location

Membrane
Nucleus
Cytoplasm
Endoplasmic reticulum
Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

PLCD4 Matched Antibody Pair (885) (CAT#: APMAB-885LY)

PLCD4 Matched Antibody Pair (886) (CAT#: APMAB-886LY)

Related Products

PLCD4 Matched Antibody Pair (885) (CAT#: APMAB-885LY)

PLCD4 Matched Antibody Pair (886) (CAT#: APMAB-886LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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