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Mouse Anti-PLCD4 Recombinant Antibody (4D4) (CBMAB-P2053-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D4
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PLCD4 (AAH06355, 18-128 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLCD4
Introduction
PLCD4 is a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol.
Entrez Gene ID
84812
UniProt ID
Q9BRC7
Alternative Names
PLC-Delta-4
Function
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Isoform 2
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.
Biological Process
Acrosome reactionIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol metabolic processIEA:InterPro
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionIDA:UniProtKB
Cellular Location
Membrane
Nucleus
Cytoplasm
Endoplasmic reticulum
Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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