Human Recombinant PLCD4 protein, GST Tag (V2LY-0526-LY6226)

Name: Human Recombinant PLCD4 protein, GST Tag
SKU: V2LY-0526-LY6226
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PLCD4 protein, GST Tag consist of Amino Acid: Full length and predicts a molecular mass of 110 kDa.

Molecule Mass

110 kDa

Sequence

Amino Acid: Full length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, DTT, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

PLCD4

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Isoform 2
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.

Biological Process

Acrosome reactionIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol metabolic processIEA:InterPro
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionIDA:UniProtKB

Cellular Location

Membrane
Nucleus
Cytoplasm
Endoplasmic reticulum
Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

PLCD4 Matched Antibody Pair (885) (CAT#: APMAB-885LY)

PLCD4 Matched Antibody Pair (886) (CAT#: APMAB-886LY)

Antibody Pairs

PLCD4 Matched Antibody Pair (885) (CAT#: APMAB-885LY)

PLCD4 Matched Antibody Pair (886) (CAT#: APMAB-886LY)

Related Products

PLCD4 Matched Antibody Pair (885) (CAT#: APMAB-885LY)

PLCD4 Matched Antibody Pair (886) (CAT#: APMAB-886LY)

Mouse Anti-PLCD4 Recombinant Antibody (4D4) (CAT#: CBMAB-P2053-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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