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Mouse Anti-PLEK Recombinant Antibody (2D8) (CBMAB-P2085-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleckstrin. The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF, WB.
See all PLEK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D8
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
PLEK (AAH18549, 121-230 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLEK
Introduction
PLEK (Pleckstrin) is a protein coding gene. Diseases associated with PLEK include Charcot-Marie-Tooth Disease, Dominant Intermediate A and Charcot-Marie-Tooth Disease, Dominant Intermediate B. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology annotations related to this gene include protein homodimerization activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of the gene is PLEK2.
Entrez Gene ID
5341
UniProt ID
P08567
Alternative Names
P47
Function
Major protein kinase C substrate of platelets.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cell projection organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIEP:BHF-UCL
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of inositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phospholipase C-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Platelet degranulationManual Assertion Based On ExperimentIEP:BHF-UCL
Positive regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of actin filament depolymerizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inositol-polyphosphate 5-phosphatase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of integrin activationISS:BHF-UCL
Positive regulation of platelet activationISS:BHF-UCL
Protein kinase C signalingISS:BHF-UCL
Protein secretion by plateletISS:BHF-UCL
Regulation of cell diameterManual Assertion Based On ExperimentIDA:BHF-UCL
Ruffle organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Vesicle docking involved in exocytosisISS:BHF-UCL
Cellular Location
cytoplasm
cytosol
extracellular region
membrane
plasma membrane
ruffle membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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