PLEK

PLEK (Pleckstrin) is a protein coding gene. Diseases associated with PLEK include Charcot-Marie-Tooth Disease, Dominant Intermediate A and Charcot-Marie-Tooth Disease, Dominant Intermediate B. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology annotations related to this gene include protein homodimerization activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of the gene is PLEK2.

Full Name

PLEK

Function

Major protein kinase C substrate of platelets.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cell projection organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIEP:BHF-UCL
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of inositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phospholipase C-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Platelet degranulationManual Assertion Based On ExperimentIEP:BHF-UCL
Positive regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of actin filament depolymerizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inositol-polyphosphate 5-phosphatase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of integrin activationISS:BHF-UCL
Positive regulation of platelet activationISS:BHF-UCL
Protein kinase C signalingISS:BHF-UCL
Protein secretion by plateletISS:BHF-UCL
Regulation of cell diameterManual Assertion Based On ExperimentIDA:BHF-UCL
Ruffle organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Vesicle docking involved in exocytosisISS:BHF-UCL

Cellular Location

cytoplasm
cytosol
extracellular region
membrane
plasma membrane
ruffle membrane