PLEK

PLEK (Pleckstrin) is a protein coding gene. Diseases associated with PLEK include Charcot-Marie-Tooth Disease, Dominant Intermediate A and Charcot-Marie-Tooth Disease, Dominant Intermediate B. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology annotations related to this gene include protein homodimerization activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of the gene is PLEK2.
Full Name
PLEK
Function
Major protein kinase C substrate of platelets.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cell projection organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIEP:BHF-UCL
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Negative regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of inositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phospholipase C-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Platelet degranulationManual Assertion Based On ExperimentIEP:BHF-UCL
Positive regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of actin filament depolymerizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inositol-polyphosphate 5-phosphatase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of integrin activationISS:BHF-UCL
Positive regulation of platelet activationISS:BHF-UCL
Protein kinase C signalingISS:BHF-UCL
Protein secretion by plateletISS:BHF-UCL
Regulation of cell diameterManual Assertion Based On ExperimentIDA:BHF-UCL
Ruffle organizationManual Assertion Based On ExperimentIDA:BHF-UCL
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Vesicle docking involved in exocytosisISS:BHF-UCL
Cellular Location
cytoplasm
cytosol
extracellular region
membrane
plasma membrane
ruffle membrane
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Anti-PLEK antibodies

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Mouse Anti-PLEK Recombinant Antibody (6E3) (CBMAB-A6792-LY)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6E3
Application*: WB, E
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (CBYC-P433) (CBMAB-P2090-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P433
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (6E7) (CBMAB-P2089-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6E7
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (6B5) (CBMAB-P2088-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B5
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (3E2) (CBMAB-P2087-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E2
Application*: F, IH, P, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (2F10) (CBMAB-P2086-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F10
Application*: F, IH, P, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (2D8) (CBMAB-P2085-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D8
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-PLEK Recombinant Antibody (2D11) (CBMAB-P2084-YC)

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Target: PLEK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2D11
Application*: F, IH, P, WB
Datasheet SDS

Human Recombinant PLEK protein, His Tag (V2LY-0526-LY6229)

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Target: PLEK
Expressed Host: E. coli
Sequence: Amino Acid: 1-350
Tag: His Tag
Datasheet SDS

PLEK Matched Antibody Pair (888) (APMAB-888LY)

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Target: PLEK
Specificity: Human
Datasheet SDS

PLEK Matched Antibody Pair (887) (APMAB-887LY)

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Target: PLEK
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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