Mouse Anti-PLEKHA3 Recombinant Antibody (2D1) (CBMAB-P2093-YC)

Name: Mouse Anti-PLEKHA3 Recombinant Antibody (2D1)
SKU: CBMAB-P2093-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D1

Application

FC, IF, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pleckstrin Homology Domain Containing A3

Introduction

PLEKHA3 (Pleckstrin Homology Domain Containing A3) is a protein coding gene. Among its related pathways are Metabolism and Cholesterol and Sphingolipids transport/Transport from Golgi and ER to the apical membrane (normal and CF). Gene Ontology annotations related to this gene include phospholipid binding and 1-phosphatidylinositol binding. An important paralog of the gene is PLEKHA8.

Entrez Gene ID

65977

UniProt ID

Q9HB20

Alternative Names

FAPP1

Function

Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860).
Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns4P) levels and activates the PtdIns4P phosphatase activity of SACM1L when it binds PtdIns4P in 'trans' configuration (PubMed:30659099).
Binds preferentially to PtdIns4P (PubMed:11001876, PubMed:15107860).
Negatively regulates APOB secretion from hepatocytes (PubMed:30659099).

Biological Process

Ceramide transportManual Assertion Based On ExperimentIBA:GO_Central
Intermembrane lipid transferManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Golgi apparatus, trans-Golgi network membrane
Localizes to ER-trans Golgi network (TGN) contacts sites.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PLEKHA3 Recombinant Antibody (6E4) (CAT#: CBMAB-P2094-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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