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Mouse Anti-PLEKHA3 Recombinant Antibody (6E4) (CBMAB-P2094-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleckstrin Homology Domain Containing A3. The antibody can be used for immunoassay techniques, such as FC, IHC-P, WB.
See all PLEKHA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E4
Antibody Isotype
IgG2a
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pleckstrin Homology Domain Containing A3
Introduction
PLEKHA3 (Pleckstrin Homology Domain Containing A3) is a protein coding gene. Among its related pathways are Metabolism and Cholesterol and Sphingolipids transport/Transport from Golgi and ER to the apical membrane (normal and CF). Gene Ontology annotations related to this gene include phospholipid binding and 1-phosphatidylinositol binding. An important paralog of the gene is PLEKHA8.
Entrez Gene ID
UniProt ID
Alternative Names
FAPP1
Function
Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860).
Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns4P) levels and activates the PtdIns4P phosphatase activity of SACM1L when it binds PtdIns4P in 'trans' configuration (PubMed:30659099).
Binds preferentially to PtdIns4P (PubMed:11001876, PubMed:15107860).
Negatively regulates APOB secretion from hepatocytes (PubMed:30659099).
Biological Process
Ceramide transportManual Assertion Based On ExperimentIBA:GO_Central
Intermembrane lipid transferManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Golgi apparatus, trans-Golgi network membrane
Localizes to ER-trans Golgi network (TGN) contacts sites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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