Mouse Anti-PLIN1 Recombinant Antibody (4G1) (CBMAB-A6801-LY)

Name: Mouse Anti-PLIN1 Recombinant Antibody (4G1)
SKU: CBMAB-A6801-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4G1

Application

WB, ELISA

Immunogen

PLIN (NP_002657.2, 101 a.a. ~ 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Perilipin 1

Introduction

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq]

Entrez Gene ID

5346

UniProt ID

O60240

Alternative Names

PERI

Function

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.

Biological Process

Cellular response to coldIEA:Ensembl
Lipid catabolic processIEA:Ensembl
Lipid metabolic process1 PublicationNAS:UniProtKB

Cellular Location

Endoplasmic reticulum
Lipid droplet
Lipid droplet surface-associated.

Involvement in disease

Lipodystrophy, familial partial, 4 (FPLD4):
A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.

PTM

Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-PLIN1 Recombinant Antibody (4G1) (CAT#: CBMAB-P2122-YC)

Related Products

Mouse Anti-PLIN1 Recombinant Antibody (PERI) (CAT#: CBMAB-P2124-YC)

Rabbit Anti-PLIN1 Recombinant Antibody (D1D8) (CAT#: CBMAB-P2123-YC)

Mouse Anti-PLIN1 Recombinant Antibody (4G1) (CAT#: CBMAB-P2122-YC)

Mouse Anti-PLIN1 Recombinant Antibody (PERI 112.17) (CAT#: CBMAB-P2125-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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