Sign in or Register   Sign in or Register
  |  

Mouse Anti-PLP1 Recombinant Antibody (538CT16.5.4) (CBMAB-R0623-CN)

This product is a Mouse antibody that recognizes PLP1. The antibody 538CT16.5.4 can be used for immunoassay techniques such as: WB, ELISA.
See all PLP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
538CT16.5.4
Antibody Isotype
IgM
Application
WB, ELISA

Basic Information

Immunogen
A KLH conjugated synthetic peptide between aa. 248-277 from the Central region of rat PIp1
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium azide

Target

Full Name
proteolipid protein 1
Introduction
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in the gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Entrez Gene ID
5354
UniProt ID
P60201
Alternative Names
PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20
Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Biological Process
AMPA selective glutamate receptor signaling pathwayIEA:Ensembl
Astrocyte developmentIEA:Ensembl
Axon developmentManual Assertion Based On ExperimentIBA:GO_Central
Axon ensheathmentManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system myelinationManual Assertion Based On ExperimentIBA:GO_Central
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseIEA:Ensembl
Long-chain fatty acid biosynthetic processIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of calcium ion transmembrane transportIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cell membrane
Myelin membrane
Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
Topology
Cytoplasmic: 2-9
Helical: 10-36
Extracellular: 37-63
Helical: 64-88
Cytoplasmic: 89-151
Helical: 152-177
Extracellular: 178-233
Helical: 234-260
Cytoplasmic: 261-277
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PLP1 Recombinant Antibody (538CT16.5.4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare