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Mouse Anti-PLP1 Recombinant Antibody (CBYC-P451) (CBMAB-P2165-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteolipid Protein 1. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all PLP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P451
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proteolipid protein 1
Introduction
PLP1 is a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2.
Entrez Gene ID
5354
UniProt ID
P60201
Alternative Names
GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2
Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Biological Process
AMPA selective glutamate receptor signaling pathwayIEA:Ensembl
Astrocyte developmentIEA:Ensembl
Axon developmentManual Assertion Based On ExperimentIBA:GO_Central
Axon ensheathmentManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system myelinationManual Assertion Based On ExperimentIBA:GO_Central
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseIEA:Ensembl
Long-chain fatty acid biosynthetic processIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of calcium ion transmembrane transportIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cell membrane
Myelin membrane
Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
Topology
Cytoplasmic: 2-9
Helical: 10-36
Extracellular: 37-63
Helical: 64-88
Cytoplasmic: 89-151
Helical: 152-177
Extracellular: 178-233
Helical: 234-260
Cytoplasmic: 261-277
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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