PLP1

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq]

proteolipid protein 1

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

AMPA selective glutamate receptor signaling pathwayIEA:Ensembl
Astrocyte developmentIEA:Ensembl
Axon developmentManual Assertion Based On ExperimentIBA:GO_Central
Axon ensheathmentManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system myelinationManual Assertion Based On ExperimentIBA:GO_Central
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseIEA:Ensembl
Long-chain fatty acid biosynthetic processIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of calcium ion transmembrane transportIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cell membrane
Myelin membrane
Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

Cytoplasmic: 2-9
Helical: 10-36
Extracellular: 37-63
Helical: 64-88
Cytoplasmic: 89-151
Helical: 152-177
Extracellular: 178-233
Helical: 234-260
Cytoplasmic: 261-277