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PLP1

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq]

Full Name

proteolipid protein 1

Function

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Biological Process

AMPA selective glutamate receptor signaling pathwayIEA:Ensembl
Astrocyte developmentIEA:Ensembl
Axon developmentManual Assertion Based On ExperimentIBA:GO_Central
Axon ensheathmentManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system myelinationManual Assertion Based On ExperimentIBA:GO_Central
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseIEA:Ensembl
Long-chain fatty acid biosynthetic processIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of calcium ion transmembrane transportIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Cell membrane
Myelin membrane
Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

Topology

Cytoplasmic: 2-9
Helical: 10-36
Extracellular: 37-63
Helical: 64-88
Cytoplasmic: 89-151
Helical: 152-177
Extracellular: 178-233
Helical: 234-260
Cytoplasmic: 261-277

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Anti-PLP1 antibodies

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Mouse Anti-PLP1 Recombinant Antibody (NYRPLP) (CBMAB-P2163-YC)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: NYRPLP

Application*: E

Mouse Anti-PLP1 Monoclonal Antibody (plpc 1) (CBMAB-1403-YC)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Cattle

Clone: plpc 1

Application*: IC, IF, IH, C, WB

Mouse Anti-PLP1 Recombinant Antibody (4H8) (CBMAB-A6808-LY)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H8

Application*: WB, E

Recombinant Mouse Anti-PLP1 Recombinant Antibody (PLPC1) (CBMAB-XB0935-YC)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Tenerife lizard

Clone: PLPC1

Application*: F, IH, IF, WB

Mouse Anti-PLP1 Recombinant Antibody (CBYC-P452) (CBMAB-P2166-YC)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-P452

Application*: IF, E, WB

Mouse Anti-PLP1 Recombinant Antibody (CBYC-P451) (CBMAB-P2165-YC)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-P451

Application*: IH, WB

Mouse Anti-PLP1 Recombinant Antibody (CBFYM-3059) (CBMAB-M3255-FY)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Cattle

Clone: CBFYM-3059

Application*: WB, IH

Mouse Anti-PLP1 Recombinant Antibody (538CT16.5.4) (CBMAB-R0623-CN)

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Target: PLP1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: 538CT16.5.4

Application*: WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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