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Mouse Anti-PMVK Recombinant Antibody (2B8) (CBMAB-A6840-LY)

The product is antibody recognizes PMVK. The antibody 2B8 immunoassay techniques such as: WB, ELISA.
See all PMVK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PMVK (AAH07694, 1 a.a. ~ 192 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphomevalonate kinase
Introduction
PMVK (EC 2.7.4.2) is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate as the fifth reaction of the cholesterol biosynthetic pathway.[supplied by OMIM
Entrez Gene ID
10654
UniProt ID
Q15126
Alternative Names
HUMPMKI; PMK; PMKA; PMKASE
Function
Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
Biological Process
Cholesterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Isopentenyl diphosphate biosynthetic process, mevalonate pathwayManual Assertion Based On ExperimentIBA:GO_Central
PhosphorylationIEA:UniProtKB-KW
Response to cholesterolManual Assertion Based On ExperimentIEP:UniProtKB
Sterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Porokeratosis 1, multiple types (POROK1):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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