Human Recombinant PMVK protein, His Tag (V2LY-0526-LY6246)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant PMVK protein, His Tag consist of Amino Acid: 1-192 and predicts a molecular mass of 23.8 kDa.
Molecule Mass
23.8 kDa
Sequence
Amino Acid: 1-192
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
phosphomevalonate kinase
Function
Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
Biological Process
Cholesterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Isopentenyl diphosphate biosynthetic process, mevalonate pathwayManual Assertion Based On ExperimentIBA:GO_Central
PhosphorylationIEA:UniProtKB-KW
Response to cholesterolManual Assertion Based On ExperimentIEP:UniProtKB
Sterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Porokeratosis 1, multiple types (POROK1):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.
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For research use only. Not intended for any clinical use.

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