Sign in or Register   Sign in or Register
  |  

PMVK

PMVK (EC 2.7.4.2) is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate as the fifth reaction of the cholesterol biosynthetic pathway.[supplied by OMIM
Full Name
phosphomevalonate kinase
Function
Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
Biological Process
Cholesterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Isopentenyl diphosphate biosynthetic process, mevalonate pathwayManual Assertion Based On ExperimentIBA:GO_Central
PhosphorylationIEA:UniProtKB-KW
Response to cholesterolManual Assertion Based On ExperimentIEP:UniProtKB
Sterol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Porokeratosis 1, multiple types (POROK1):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.

Anti-PMVK antibodies

Loading...
Target: PMVK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B8
Application*: WB, E
Target: PMVK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2F9
Application*: F, IF, WB
Target: PMVK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 21C10
Application*: E, WB, IC, IF, F
Target: PMVK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C12
Application*: IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare