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Mouse Anti-POLE3 Recombinant Antibody (2C7) (CBMAB-P2324-YC)

Provided herein is a Mouse monoclonal antibody against Human DNA Polymerase Epsilon 3, Accessory Subunit. The antibody can be used for immunoassay techniques, such as IP.
See all POLE3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C7
Antibody Isotype
IgG1
Application
IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POLE3
Introduction
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Entrez Gene ID
54107
UniProt ID
Q9NRF9
Alternative Names
CHARAC17; YBL1; CHRAC17; p17
Function
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIBA:GO_Central
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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