Mouse Anti-POLE3 Antibody (2F10) (CBMAB-0825-YC)

Name: Mouse Anti-POLE3 Antibody (2F10)
SKU: CBMAB-0825-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2F10

Application

IP, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

POLE3

Introduction

POLE3 (polymerase (DNA directed), epsilon 3, accessory subunit) is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

Entrez Gene ID

54107

UniProt ID

Q9NRF9

Alternative Names

CHARAC17; CHRAC17; p17; Ybl1

Function

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIBA:GO_Central
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

POLE3 Matched Antibody Pair (904) (CAT#: APMAB-904LY)

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POLE3 Matched Antibody Pair (904) (CAT#: APMAB-904LY)

Mouse Anti-POLE3 Antibody (2B11) (CAT#: CBMAB-0824-YC)

Mouse Anti-POLE3 Antibody (3D3) (CAT#: CBMAB-0828-YC)

Mouse Anti-POLE3 Recombinant Antibody (3C5.1) (CAT#: CBMAB-P2325-YC)

Mouse Anti-POLE3 Recombinant Antibody (4B5) (CAT#: CBMAB-P2326-YC)

Mouse Anti-POLE3 Recombinant Antibody (2C7) (CAT#: CBMAB-P2324-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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