POLE3
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Full Name
POLE3
Function
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIBA:GO_Central
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Cellular Location
Nucleus
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Anti-POLE3 antibodies
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CompareTarget: POLE3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D3
Application*: IP, M
Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F10
Application*: IP, M
Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B11
Application*: IP, WB, M
Target: POLE3
Specificity: Human
Target: POLE3
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLC252-LY
Application*: WB, IP, IF, E
Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B5
Application*: IP
Target: POLE3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Hamster
Clone: 3C5.1
Application*: IP, WB
Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C7
Application*: IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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