POLE3

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Full Name
POLE3
Function
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIBA:GO_Central
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Cellular Location
Nucleus
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Anti-POLE3 antibodies

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Mouse Anti-POLE3 Antibody (3D3) (CBMAB-0828-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D3
Application*: IP, M
Datasheet SDS

Mouse Anti-POLE3 Antibody (2F10) (CBMAB-0825-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F10
Application*: IP, M
Datasheet SDS

Mouse Anti-POLE3 Antibody (2B11) (CBMAB-0824-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B11
Application*: IP, WB, M
Datasheet SDS

POLE3 Matched Antibody Pair (904) (APMAB-904LY)

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Target: POLE3
Specificity: Human
Datasheet SDS

Mouse Anti-POLE3 Recombinant Antibody (CBLC252-LY) (CBMAB-C12214-LY)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLC252-LY
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-POLE3 Recombinant Antibody (4B5) (CBMAB-P2326-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B5
Application*: IP
Datasheet SDS

Mouse Anti-POLE3 Recombinant Antibody (3C5.1) (CBMAB-P2325-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Hamster
Clone: 3C5.1
Application*: IP, WB
Datasheet SDS

Mouse Anti-POLE3 Recombinant Antibody (2C7) (CBMAB-P2324-YC)

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Target: POLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C7
Application*: IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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