POLE3

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

POLE3

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).
Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).
Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIBA:GO_Central
Chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Leading strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Nucleosome assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal

Nucleus