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Mouse Anti-POU2F1 Recombinant Antibody (CBXO-0463) (CBMAB-O0257-CQ)

This product is a mouse antibody that recognizes POU2F1. The antibody CBXO-0463 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P.
See all POU2F1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human, Frog
Clone
CBXO-0463
Application
WB, IP, IF, IHC-P

Basic Information

Specificity
Mouse, Human, Frog
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POU class 2 homeobox 1
Introduction
POU2F1 was among the first identified members of the POU transcription factor family. POU2F1 contains the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.
Entrez Gene ID
Human5451
Mouse18986
Frog549091
UniProt ID
HumanP14859
MouseP25425
FrogP16143
Alternative Names
POU2F1; POU class 2 homeobox 1; OTF1, POU domain class 2, transcription factor 1; POU domain, class 2, transcription factor 1; OCT1; NF-A1; OTF-1; oct-1; octamer-binding protein 1; Octamer-binding transcription factor-1; octamer-binding transcription factor 1; OTF1
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Biological Process
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated by PRKDC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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