POU2F1

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.

Full Name

POU class 2 homeobox 1

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Biological Process

Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

PTM

Phosphorylated by PRKDC.

Anti-POU2F1 antibodies

Mouse Anti-POU2F1 Recombinant Antibody (CBCNC-685) (CBMAB-C4135-CN)

Datasheet

SDS

Target: POU2F1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-685

Application*: WB, P

Mouse Anti-POU2F1 Recombinant Antibody (27-7G1) (CBMAB-C4133-CN)

Datasheet

SDS

Target: POU2F1

Host: Mouse

Specificity: Human

Clone: 27-7G1

Application*: WB

Mouse Anti-POU2F1 Recombinant Antibody (YL15) (CBMAB-P2435-YC)

Datasheet

SDS

Target: POU2F1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: YL15

Application*: EMSA, IP, WB

Mouse Anti-POU2F1 Recombinant Antibody (CBXO-0463) (CBMAB-O0257-CQ)

Datasheet

SDS

Target: POU2F1

Host: Mouse

Specificity: Mouse, Human, Frog

Clone: CBXO-0463

Application*: WB, IP, IF, P

Datasheet

SDS

Target: POU2F1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1E12

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)