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Mouse Anti-PPME1 Recombinant Antibody (10A12) (CBMAB-P2571-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase Methylesterase 1. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC, IHC-P, WB.
See all PPME1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10A12
Antibody Isotype
IgG2a
Application
FC, ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human PPME1 (NP_057231) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase Methylesterase 1
Introduction
PPME1 is a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression.
Entrez Gene ID
51400
UniProt ID
Q9Y570
Alternative Names
PME-1
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Biological Process
G2/M transition of mitotic cell cycleTAS:Reactome
Protein demethylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein phosphorylationIEA:Ensembl
Cellular Location
Nucleoplasm
PTM
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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