Human Recombinant PPME1 protein, GST Tag (V2LY-0526-LY6272)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant PPME1 protein, GST Tag consist of Amino Acid: 2-end and predicts a molecular mass of 70 kDa.
Molecule Mass
70 kDa
Sequence
Amino Acid: 2-end
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, DTT, Glycerol
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Protein Phosphatase Methylesterase 1
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Biological Process
G2/M transition of mitotic cell cycleTAS:Reactome
Protein demethylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein phosphorylationIEA:Ensembl
Cellular Location
Nucleoplasm
PTM
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
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For research use only. Not intended for any clinical use.

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