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PPME1

PPME1 is a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression.
Full Name
Protein Phosphatase Methylesterase 1
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Biological Process
G2/M transition of mitotic cell cycleTAS:Reactome
Protein demethylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein phosphorylationIEA:Ensembl
Cellular Location
Nucleoplasm
PTM
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
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Anti-PPME1 antibodies

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Mouse Anti-PPME1 Recombinant Antibody (29G3) (CBMAB-P2573-YC)

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Target: PPME1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 29G3
Application*: WB, E, IC, IF
Datasheet SDS

Mouse Anti-PPME1 Recombinant Antibody (10B2) (CBMAB-P2572-YC)

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Target: PPME1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-PPME1 Recombinant Antibody (10A12) (CBMAB-P2571-YC)

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Target: PPME1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10A12
Application*: F, IC, IF, IH, P, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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