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PPME1

PPME1 is a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression.

Full Name

Protein Phosphatase Methylesterase 1

Function

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Biological Process

G2/M transition of mitotic cell cycleTAS:Reactome
Protein demethylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein phosphorylationIEA:Ensembl

Cellular Location

Nucleoplasm

PTM

Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.

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Anti-PPME1 antibodies

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Mouse Anti-PPME1 Recombinant Antibody (29G3) (CBMAB-P2573-YC)

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Target: PPME1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 29G3

Application*: WB, E, IC, IF

Mouse Anti-PPME1 Recombinant Antibody (10B2) (CBMAB-P2572-YC)

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Target: PPME1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B2

Application*: F, IC, IF, WB

Mouse Anti-PPME1 Recombinant Antibody (10A12) (CBMAB-P2571-YC)

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Target: PPME1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10A12

Application*: F, IC, IF, IH, P, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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