Mouse Anti-PRAG1 Recombinant Antibody (1D9) (CBMAB-A6992-LY)

Name: Mouse Anti-PRAG1 Recombinant Antibody (1D9)
SKU: CBMAB-A6992-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1D9

Application

WB, ELISA

Immunogen

PRAGMIN (XP_291277, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

PEAK1 related, kinase-activating pseudokinase 1

Entrez Gene ID

157285

UniProt ID

Q86YV5

Alternative Names

DKFZp761P0423

Function

Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity).
Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity).
Acts as a critical coactivator of Notch signaling (By similarity).

Biological Process

Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Positive regulation of Rho protein signal transductionISS:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell motilityISS:UniProtKB
Regulation of cell shapeISS:UniProtKB
Regulation of Notch signaling pathwayISS:UniProtKB

Cellular Location

Cytoplasm
Cell junction, focal adhesion
Nucleus
Colocalized with NOTCH1 in the nucleus.

PTM

Phosphorylated by CSK on Tyr-253, Tyr-365, and Tyr-413; Tyr-413 is a primary site of phosphorylation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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