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Mouse Anti-PRDM5 Recombinant Antibody (7D4C12) (CBMAB-P2718-YC)

Provided herein is a Mouse monoclonal antibody against Human PR/SET Domain 5. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, IHC.
See all PRDM5 antibodies
Published Data
Fig.1 Upregulation of PRDM5 in AML is associated with poor prognosis and survival.
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Fig.2 PRDM5 overexpression promotes the growth and migration of U937 AML cells.
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Fig.3 PRDM5 induces AML cells proliferation and migration through promoting cell cycle progression and EMT accompanied with JNK pathway activation and c‐Myc downregulation.
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Fig.4 The JNK inhibitor SP600125 inhibits the JNK signaling pathway and rescues the effects of PRDM5 overexpression in U937 cells.
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Fig.5 PRDM5 overexpression accelerates the growth of OCI‐AML leukemic xenograft tumors.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
7D4C12
Antibody Isotype
IgG
Application
WB, FC, ELISA, IHC

Basic Information

Immunogen
Purified recombinant fragment of human PRDM5 (AA 1-100) expressed in E. coli
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRDM5
Introduction
PRDM5 is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.
Entrez Gene ID
Human11107
Mouse70779
UniProt ID
HumanQ9NQX1
MouseQ9CXE0
Alternative Names
BCS2; PFM2
Function
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Histone deacetylationManual Assertion Based On ExperimentIMP:UniProtKB
Histone H3-K9 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of extracellular matrix organizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Brittle cornea syndrome 2 (BCS2):
A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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