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Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397)


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Tested Data
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in ELISA
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in ELISA
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in WB
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in FC
Mouse Anti-PRDM5 Recombinant Antibody (CBT2283) (V2LY-0625-LY397) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2283
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human PRDM5 (AA: 1-100) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PRDM5
Entrez Gene ID
11107
UniProt ID
Q9NQX1
Function
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Histone deacetylationManual Assertion Based On ExperimentIMP:UniProtKB
Histone H3-K9 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of extracellular matrix organizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Brittle cornea syndrome 2 (BCS2):
A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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