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Rabbit Anti-PRKAR1A Recombinant Antibody (D54D9) (CBMAB-P2808-YC)

Provided herein is a Rabbit monoclonal antibody against Human Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PRKAR1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Monkey
Clone
D54D9
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Hamster, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase cAMP-dependent type I regulatory subunit alpha
Introduction
PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha) is a protein coding gene. Diseases associated with PRKAR1A include Myxoma, Intracardiac andCarney Complex, Type 1. Among its related pathways are Melanocyte Development and Pigmentation and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology annotations related to this gene include ubiquitin protein ligase binding and protein kinase A catalytic subunit binding.
Entrez Gene ID
Human5573
Mouse19084
Rat25725
Monkey719021
Hamster100773792
UniProt ID
HumanP10644
MouseQ9DBC7
RatP09456
MonkeyF6WM87
HamsterP86244
Alternative Names
ACRDYS1; ADOHR; CAR; CNC; CNC1; PKR1; PPNAD1; PRKAR1; TSE1
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Biological Process
Cardiac muscle cell proliferationIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Mesoderm formationIEA:Ensembl
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Sarcomere organizationIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Carney complex 1 (CNC1):
CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
Intracardiac myxoma (INTMYX):
Inheritance is autosomal recessive.
Primary pigmented nodular adrenocortical disease 1 (PPNAD1):
A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. PPNAD1 is most often diagnosed in patients with Carney complex, a multiple neoplasia syndrome. However it can also be observed in patients without other manifestations.
Acrodysostosis 1, with or without hormone resistance (ACRDYS1):
A form of skeletal dysplasia characterized by short stature, severe brachydactyly, facial dysostosis, and nasal hypoplasia. Affected individuals often have advanced bone age and obesity. Laboratory studies show resistance to multiple hormones, including parathyroid, thyrotropin, calcitonin, growth hormone-releasing hormone, and gonadotropin. However, not all patients show endocrine abnormalities.
PTM
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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