Human Recombinant PRKAR1A protein, His Tag-1 (V2LY-0526-LY6302)

Name: Human Recombinant PRKAR1A protein, His Tag-1
SKU: V2LY-0526-LY6302
Rating: 5 (1 reviews)

See all PRKAR1A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant PRKAR1A protein, His Tag consist of Amino Acid: 1-381 and predicts a molecular mass of 44.3 kDa.

Molecule Mass

44.3 kDa

Sequence

Amino Acid: 1-381

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

protein kinase cAMP-dependent type I regulatory subunit alpha

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Biological Process

Cardiac muscle cell proliferationIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Mesoderm formationIEA:Ensembl
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Sarcomere organizationIEA:Ensembl

Cellular Location

Cell membrane

Involvement in disease

Carney complex 1 (CNC1):
CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
Intracardiac myxoma (INTMYX):
Inheritance is autosomal recessive.
Primary pigmented nodular adrenocortical disease 1 (PPNAD1):
A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. PPNAD1 is most often diagnosed in patients with Carney complex, a multiple neoplasia syndrome. However it can also be observed in patients without other manifestations.
Acrodysostosis 1, with or without hormone resistance (ACRDYS1):
A form of skeletal dysplasia characterized by short stature, severe brachydactyly, facial dysostosis, and nasal hypoplasia. Affected individuals often have advanced bone age and obesity. Laboratory studies show resistance to multiple hormones, including parathyroid, thyrotropin, calcitonin, growth hormone-releasing hormone, and gonadotropin. However, not all patients show endocrine abnormalities.

PTM

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant PRKAR1A protein, His Tag-1?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PRKAR1A protein, His Tag (CAT#: V2LY-0526-LY6301)

Mouse Recombinant PRKAR1A protein, His Tag (CAT#: V2LY-0526-LY8797)

Related Products

Rabbit Anti-PRKAR1A Recombinant Antibody (EG1736) (CAT#: CBMAB-EN2074-LY)

Human Recombinant PRKAR1A protein, His Tag (CAT#: V2LY-0526-LY6301)

Rabbit Anti-PRKAR1A Recombinant Antibody (
1C3) (CAT#: V2LY-0725-LY852)

Mouse Recombinant PRKAR1A protein, His Tag (CAT#: V2LY-0526-LY8797)

Rabbit Anti-PRKAR1A Recombinant Antibody (D54D9) (CAT#: CBMAB-P2808-YC)

Rabbit Anti-PRKAR1A Recombinant Antibody (CBNH-089) (CAT#: CBMAB-R4414-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry