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Mouse Anti-PRKAR1B Recombinant Antibody (1B4) (CBMAB-P2810-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta. The antibody can be used for immunoassay techniques, such as IF, WB.
See all PRKAR1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B4
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase cAMP-dependent type I regulatory subunit beta
Introduction
PRKAR1B is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription.
Entrez Gene ID
5575
UniProt ID
P31321
Alternative Names
PRKAR1
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Biological Process
Learning or memoryIEA:Ensembl
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Positive regulation of fear responseIEA:Ensembl
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Protein phosphorylation1 PublicationNAS:UniProtKB
Regulation of synaptic vesicle cycleIEA:Ensembl
Cellular Location
Cell membrane
PTM
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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