PRKAR1B

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene.
Full Name
protein kinase cAMP-dependent type I regulatory subunit beta
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Biological Process
Learning or memoryIEA:Ensembl
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Positive regulation of fear responseIEA:Ensembl
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Protein phosphorylation1 PublicationNAS:UniProtKB
Regulation of synaptic vesicle cycleIEA:Ensembl
Cellular Location
Cell membrane
PTM
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
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Anti-PRKAR1B antibodies

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Mouse Anti-PRKAR1B Recombinant Antibody (2A3) (CBMAB-P2811-YC)

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Target: PRKAR1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A3
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PRKAR1B Recombinant Antibody (1B4) (CBMAB-P2810-YC)

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Target: PRKAR1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: IF, WB
Datasheet SDS

Rabbit Anti-PRKAR1B Recombinant Antibody (EG1737) (CBMAB-EN2075-LY)

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Target: PRKAR1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1737
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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