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PRKAR1B

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene.
Full Name
protein kinase cAMP-dependent type I regulatory subunit beta
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Biological Process
Learning or memoryIEA:Ensembl
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Positive regulation of fear responseIEA:Ensembl
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Protein phosphorylation1 PublicationNAS:UniProtKB
Regulation of synaptic vesicle cycleIEA:Ensembl
Cellular Location
Cell membrane
PTM
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

Anti-PRKAR1B antibodies

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Target: PRKAR1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1737
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Target: PRKAR1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A3
Application*: F, IF, WB
Target: PRKAR1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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